Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

Anna Tchenio, Salvatore Lecca, Kristina Valentinova and Manuel Mameli ()
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Anna Tchenio: Institut du Fer à Moulin
Salvatore Lecca: Institut du Fer à Moulin
Kristina Valentinova: Institut du Fer à Moulin
Manuel Mameli: Institut du Fer à Moulin

Nature Communications, 2017, vol. 8, issue 1, 1-8

Abstract: Abstract Early-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS drives reduction of GABAB-GIRK signaling and the subsequent lateral habenula (LHb) hyperexcitability—an anatomical substrate devoted to aversive encoding. Attenuating LHb hyperactivity using chemogenetic tools and deep-brain stimulation ameliorates MS depressive-like symptoms. This provides insights on mechanisms and strategies to alleviate stress-dependent affective behaviors.

Date: 2017
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DOI: 10.1038/s41467-017-01192-1

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