DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress

Bing Yao, Ying Cheng, Zhiqin Wang, Yujing Li, Li Chen, Luoxiu Huang, Wenxin Zhang, Dahua Chen, Hao Wu, Beisha Tang and Peng Jin ()
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Bing Yao: Emory University School of Medicine
Ying Cheng: Emory University School of Medicine
Zhiqin Wang: Central South University
Yujing Li: Emory University School of Medicine
Li Chen: Emory University School of Medicine
Luoxiu Huang: Emory University School of Medicine
Wenxin Zhang: Chinese Academy of Sciences
Dahua Chen: Chinese Academy of Sciences
Hao Wu: Emory University School of Public Health
Beisha Tang: Central South University
Peng Jin: Emory University School of Medicine

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract Chemical modifications on DNA molecules, such as 5-methylcytosine and 5-hydroxymethylcytosine, play important roles in the mammalian brain. A novel DNA adenine modification, N(6)-methyladenine (6mA), has recently been found in mammalian cells. However, the presence and function(s) of 6mA in the mammalian brain remain unclear. Here we demonstrate 6mA dynamics in the mouse brain in response to environmental stress. We find that overall 6mA levels are significantly elevated upon stress. Genome-wide 6mA and transcriptome profiling reveal an inverse association between 6mA dynamic changes and a set of upregulated neuronal genes or downregulated LINE transposon expression. Genes bearing stress-induced 6mA changes significantly overlap with loci associated with neuropsychiatric disorders. These results suggest an epigenetic role for 6mA in the mammalian brain as well as its potential involvement in neuropsychiatric disorders.

Date: 2017
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DOI: 10.1038/s41467-017-01195-y

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