Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma

Jennifer Ducie, Fanny Dao, Michael Considine, Narciso Olvera, Patricia A. Shaw, Robert J. Kurman, Ie-Ming Shih, Robert A. Soslow, Leslie Cope and Douglas A. Levine ()
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Jennifer Ducie: Memorial Sloan Kettering Cancer Center
Fanny Dao: Memorial Sloan Kettering Cancer Center
Michael Considine: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Narciso Olvera: Memorial Sloan Kettering Cancer Center
Patricia A. Shaw: University Health Network
Robert J. Kurman: Johns Hopkins Medical Institutions
Ie-Ming Shih: Johns Hopkins Medical Institutions
Robert A. Soslow: Memorial Sloan Kettering Cancer Center
Leslie Cope: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Douglas A. Levine: Memorial Sloan Kettering Cancer Center

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract Many high-grade serous carcinomas (HGSCs) of the pelvis are thought to originate in the distal portion of the fallopian tube. Serous tubal intra-epithelial carcinoma (STIC) lesions are the putative precursor to HGSC and identifiable in ~ 50% of advanced stage cases. To better understand the molecular etiology of HGSCs, we report a multi-center integrated genomic analysis of advanced stage tumors with and without STIC lesions and normal tissues. The most significant focal DNA SCNAs were shared between cases with and without STIC lesions. The RNA sequence and the miRNA data did not identify any clear separation between cases with and without STIC lesions. HGSCs had molecular profiles more similar to normal fallopian tube epithelium than ovarian surface epithelium or peritoneum. The data suggest that the molecular features of HGSCs with and without associated STIC lesions are mostly shared, indicating a common biologic origin, likely to be the distal fallopian tube among all cases.

Date: 2017
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DOI: 10.1038/s41467-017-01217-9

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