Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator

A. Chen, P. D. Arora, C. A. McCulloch and A. Wilde ()
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A. Chen: University of Toronto
P. D. Arora: University of Toronto
C. A. McCulloch: University of Toronto
A. Wilde: University of Toronto

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract Cytokinesis is initiated by the localized assembly of the contractile ring, a dynamic actomyosin structure that generates a membrane furrow between the segregating chromosomal masses to divide a cell into two. Here we show that the stabilization and organization of the cytokinetic furrow is specifically dependent on localized β-actin filament assembly at the site of cytokinesis. β-actin filaments are assembled directly at the furrow by an anillin-dependent pathway that enhances RhoA-dependent activation of the formin DIAPH3, an actin nucleator. DIAPH3 specifically generates homopolymeric filaments of β-actin in vitro. By employing enhancers and activators, cells can achieve acute spatio-temporal control over isoform-specific actin arrays that are required for distinct cellular functions.

Date: 2017
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DOI: 10.1038/s41467-017-01231-x

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