The North American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA

S. Austin Hammond, René L. Warren, Benjamin P. Vandervalk, Erdi Kucuk, Hamza Khan, Ewan A. Gibb, Pawan Pandoh, Heather Kirk, Yongjun Zhao, Martin Jones, Andrew J. Mungall, Robin Coope, Stephen Pleasance, Richard A. Moore, Robert A. Holt, Jessica M. Round, Sara Ohora, Branden V. Walle, Nik Veldhoen, Caren C. Helbing () and Inanc Birol ()
Additional contact information
S. Austin Hammond: BC Cancer Agency
René L. Warren: BC Cancer Agency
Benjamin P. Vandervalk: BC Cancer Agency
Erdi Kucuk: BC Cancer Agency
Hamza Khan: BC Cancer Agency
Ewan A. Gibb: BC Cancer Agency
Pawan Pandoh: BC Cancer Agency
Heather Kirk: BC Cancer Agency
Yongjun Zhao: BC Cancer Agency
Martin Jones: BC Cancer Agency
Andrew J. Mungall: BC Cancer Agency
Robin Coope: BC Cancer Agency
Stephen Pleasance: BC Cancer Agency
Richard A. Moore: BC Cancer Agency
Robert A. Holt: BC Cancer Agency
Jessica M. Round: University of Victoria
Sara Ohora: University of Victoria
Branden V. Walle: University of Victoria
Nik Veldhoen: University of Victoria
Caren C. Helbing: University of Victoria
Inanc Birol: BC Cancer Agency

Nature Communications, 2017, vol. 8, issue 1, 1-8

Abstract: Abstract Frogs play important ecological roles, and several species are important model organisms for scientific research. The globally distributed Ranidae (true frogs) are the largest frog family, and have substantial evolutionary distance from the model laboratory Xenopus frog species. Unfortunately, there are currently no genomic resources for the former, important group of amphibians. More widely applicable amphibian genomic data is urgently needed as more than two-thirds of known species are currently threatened or are undergoing population declines. We report a 5.8 Gbp (NG50 = 69 kbp) genome assembly of a representative North American bullfrog (Rana [Lithobates] catesbeiana). The genome contains over 22,000 predicted protein-coding genes and 6,223 candidate long noncoding RNAs (lncRNAs). RNA-Seq experiments show thyroid hormone causes widespread transcriptional change among protein-coding and putative lncRNA genes. This initial bullfrog draft genome will serve as a key resource with broad utility including amphibian research, developmental biology, and environmental research.

Date: 2017
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DOI: 10.1038/s41467-017-01316-7

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