Large-scale suppression of recombination predates genomic rearrangements in Neurospora tetrasperma

Yu Sun, Jesper Svedberg, Markus Hiltunen, Pádraic Corcoran and Hanna Johannesson ()
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Yu Sun: Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University
Jesper Svedberg: Uppsala University
Markus Hiltunen: Uppsala University
Pádraic Corcoran: University of Sheffield
Hanna Johannesson: Uppsala University

Nature Communications, 2017, vol. 8, issue 1, 1-8

Abstract: Abstract A common feature of eukaryote genomes is large chromosomal regions where recombination is absent or strongly reduced, but the factors that cause this reduction are not well understood. Genomic rearrangements have often been implicated, but they may also be a consequence of recombination suppression rather than a cause. In this study, we generate eight high-quality genomic data sets of the filamentous ascomycete Neurospora tetrasperma, a fungus that lacks recombination over most of its largest chromosome. The genomes surprisingly reveal collinearity of the non-recombining regions and although large inversions are enriched in these regions, we conclude these inversions to be derived and not the cause of the suppression. To our knowledge, this is the first time that non-recombining, genic regions as large as 86% of a full chromosome (or 8 Mbp), are shown to be collinear. These findings are of significant interest for our understanding of the evolution of sex chromosomes and other supergene complexes.

Date: 2017
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DOI: 10.1038/s41467-017-01317-6

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