History-based action selection bias in posterior parietal cortex

Eun Jung Hwang (), Jeffrey E. Dahlen, Madan Mukundan and Takaki Komiyama ()
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Eun Jung Hwang: University of California, San Diego
Jeffrey E. Dahlen: University of California, San Diego
Madan Mukundan: University of California, San Diego
Takaki Komiyama: University of California, San Diego

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract Making decisions based on choice-outcome history is a crucial, adaptive ability in life. However, the neural circuit mechanisms underlying history-dependent decision-making are poorly understood. In particular, history-related signals have been found in many brain areas during various decision-making tasks, but the causal involvement of these signals in guiding behavior is unclear. Here we addressed this issue utilizing behavioral modeling, two-photon calcium imaging, and optogenetic inactivation in mice. We report that a subset of neurons in the posterior parietal cortex (PPC) closely reflect the choice-outcome history and history-dependent decision biases, and PPC inactivation diminishes the history dependency of choice. Specifically, many PPC neurons show history- and bias-tuning during the inter-trial intervals (ITI), and history dependency of choice is affected by PPC inactivation during ITI and not during trial. These results indicate that PPC is a critical region mediating the subjective use of history in biasing action selection.

Date: 2017
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DOI: 10.1038/s41467-017-01356-z

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