Polymer mimics of biomacromolecular antifreezes

Caroline I. Biggs, Trisha L. Bailey, Graham, Christopher Stubbs, Alice Fayter and Matthew I. Gibson ()
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Caroline I. Biggs: University of Warwick
Trisha L. Bailey: University of Warwick
Graham: University of Warwick
Christopher Stubbs: University of Warwick
Alice Fayter: University of Warwick
Matthew I. Gibson: University of Warwick

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Antifreeze proteins from polar fish species are remarkable biomacromolecules which prevent the growth of ice crystals. Ice crystal growth is a major problem in cell/tissue cryopreservation for transplantation, transfusion and basic biomedical research, as well as technological applications such as icing of aircraft wings. This review will introduce the rapidly emerging field of synthetic macromolecular (polymer) mimics of antifreeze proteins. Particular focus is placed on designing polymers which have no structural similarities to antifreeze proteins but reproduce the same macroscopic properties, potentially by different molecular-level mechanisms. The application of these polymers to the cryopreservation of donor cells is also introduced.

Date: 2017
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DOI: 10.1038/s41467-017-01421-7

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