Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

Michael P. Plebanek, Nicholas L. Angeloni, Elena Vinokour, Jia Li, Anna Henkin, Dalia Martinez-Marin, Stephanie Filleur, Reshma Bhowmick, Jack Henkin, Stephen D. Miller, Igal Ifergan, Yesung Lee, Iman Osman, C. Shad Thaxton and Olga V. Volpert ()
Additional contact information
Michael P. Plebanek: Northwestern University Feinberg School of Medicine
Nicholas L. Angeloni: Northwestern University Feinberg School of Medicine
Elena Vinokour: Northwestern University Feinberg School of Medicine
Jia Li: Northwestern University Feinberg School of Medicine
Anna Henkin: Massachusetts Institute of Technology
Dalia Martinez-Marin: Texas Tech University Health Sciences Center
Stephanie Filleur: Texas Tech University Health Sciences Center
Reshma Bhowmick: University of Texas MD Anderson Cancer Center
Jack Henkin: Northwestern University
Stephen D. Miller: Northwestern University Feinberg School of Medicine
Igal Ifergan: Northwestern University Feinberg School of Medicine
Yesung Lee: New York University School of Medicine
Iman Osman: New York University School of Medicine
C. Shad Thaxton: Northwestern University Feinberg School of Medicine
Olga V. Volpert: University of Texas MD Anderson Cancer Center

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Metastatic cancers produce exosomes that condition pre-metastatic niches in remote microenvironments to favor metastasis. In contrast, here we show that exosomes from poorly metastatic melanoma cells can potently inhibit metastasis to the lung. These “non-metastatic” exosomes stimulate an innate immune response through the expansion of Ly6Clow patrolling monocytes (PMo) in the bone marrow, which then cause cancer cell clearance at the pre-metastatic niche, via the recruitment of NK cells and TRAIL-dependent killing of melanoma cells by macrophages. These events require the induction of the Nr4a1 transcription factor and are dependent on pigment epithelium-derived factor (PEDF) on the outer surface of exosomes. Importantly, exosomes isolated from patients with non-metastatic primary melanomas have a similar ability to suppress lung metastasis. This study thus demonstrates that pre-metastatic tumors produce exosomes, which elicit a broad range of PMo-reliant innate immune responses via trigger(s) of immune surveillance, causing cancer cell clearance at the pre-metastatic niche.

Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-017-01433-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01433-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-017-01433-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().