Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota

Gregorio Iraola (), Samuel C. Forster, Nitin Kumar, Philippe Lehours, Sadjia Bekal, Francisco J. García-Peña, Fernando Paolicchi, Claudia Morsella, Helmut Hotzel, Po-Ren Hsueh, Ana Vidal, Simon Lévesque, Wataru Yamazaki, Claudia Balzan, Agueda Vargas, Alessandra Piccirillo, Bonnie Chaban, Janet E. Hill, Laura Betancor, Luis Collado, Isabelle Truyers, Anne C. Midwinter, Hatice T. Dagi, Francis Mégraud, Lucía Calleros, Ruben Pérez, Hugo Naya and Trevor D. Lawley ()
Additional contact information
Gregorio Iraola: Institut Pasteur Montevideo
Samuel C. Forster: Wellcome Trust Sanger Institute
Nitin Kumar: Wellcome Trust Sanger Institute
Philippe Lehours: INSERM UMR1053, University of Bordeaux
Sadjia Bekal: Institut National de Santé Publique du Québec
Francisco J. García-Peña: Laboratorio Central de Veterinaria de Algete (MAGRAMA)
Fernando Paolicchi: EEA-INTA Balcarce
Claudia Morsella: EEA-INTA Balcarce
Helmut Hotzel: Institute of Bacterial Infections and Zoonoses
Po-Ren Hsueh: National Taiwan University Hospital
Ana Vidal: Animal and Plant Health Association (APHA)
Simon Lévesque: Institut National de Santé Publique du Québec
Wataru Yamazaki: Faculty of Agriculture, University of Miyazaki
Claudia Balzan: Universidade Federal de Santa Maria
Agueda Vargas: Universidade Federal de Santa Maria
Alessandra Piccirillo: University of Padova
Bonnie Chaban: Health, Education and Engineering, University of the Sunshine Coast
Janet E. Hill: University of Saskatchewan
Laura Betancor: Facultad de Medicina, Universidad de la República
Luis Collado: Facultad de Ciencias, Universidad Austral de Chile
Isabelle Truyers: University of Edinburgh
Anne C. Midwinter: Massey University
Hatice T. Dagi: Faculty of Medicine, Selçuk University
Francis Mégraud: INSERM UMR1053, University of Bordeaux
Lucía Calleros: Facultad de Ciencias, Universidad de la República
Ruben Pérez: Facultad de Ciencias, Universidad de la República
Hugo Naya: Institut Pasteur Montevideo
Trevor D. Lawley: Wellcome Trust Sanger Institute

Nature Communications, 2017, vol. 8, issue 1, 1-8

Abstract: Abstract Campylobacter fetus is a venereal pathogen of cattle and sheep, and an opportunistic human pathogen. It is often assumed that C. fetus infection occurs in humans as a zoonosis through food chain transmission. Here we show that mammalian C. fetus consists of distinct evolutionary lineages, primarily associated with either human or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence that C. fetus may have originated in humans around 10,500 years ago and may have “jumped” into cattle during the livestock domestication period. We detect C. fetus genomes in 8% of healthy human fecal metagenomes, where the human-associated lineages are the dominant type (78%). Thus, our work suggests that C. fetus is an unappreciated human intestinal pathobiont likely spread by human to human transmission. This genome-based evolutionary framework will facilitate C. fetus epidemiology research and the development of improved molecular diagnostics and prevention schemes for this neglected pathogen.

Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-017-01449-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01449-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-017-01449-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().