Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB

Simon N. Willis (), Julie Tellier, Yang Liao, Stephanie Trezise, Amanda Light, Kristy O’Donnell, Lee Ann Garrett-Sinha, Wei Shi, David M. Tarlinton and Stephen L. Nutt ()
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Simon N. Willis: 1G Royal Parade
Julie Tellier: 1G Royal Parade
Yang Liao: 1G Royal Parade
Stephanie Trezise: 1G Royal Parade
Amanda Light: 1G Royal Parade
Kristy O’Donnell: 1G Royal Parade
Lee Ann Garrett-Sinha: State University of New York at Buffalo
Wei Shi: 1G Royal Parade
David M. Tarlinton: 1G Royal Parade
Stephen L. Nutt: 1G Royal Parade

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract Humoral immunity requires B cells to respond to multiple stimuli, including antigen, membrane and soluble ligands, and microbial products. Ets family transcription factors regulate many aspects of haematopoiesis, although their functions in humoral immunity are difficult to decipher as a result of redundancy between the family members. Here we show that mice lacking both PU.1 and SpiB in mature B cells do not generate germinal centers and high-affinity antibody after protein immunization. PU.1 and SpiB double-deficient B cells have a survival defect after engagement of CD40 or Toll-like receptors (TLR), despite paradoxically enhanced plasma cell differentiation. PU.1 and SpiB regulate the expression of many components of the B cell receptor signaling pathway and the receptors for CD40L, BAFF and TLR ligands. Thus, PU.1 and SpiB enable B cells to appropriately respond to environmental cues.

Date: 2017
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DOI: 10.1038/s41467-017-01605-1

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