O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress

Cuifang Han, Yuchao Gu (), Hui Shan, Wenyi Mi, Jiahui Sun, Minghui Shi, Xinling Zhang, Xinzhi Lu, Feng Han, Qianhong Gong and Wengong Yu ()
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Cuifang Han: Ocean University of China
Yuchao Gu: Ocean University of China
Hui Shan: Ocean University of China
Wenyi Mi: Ocean University of China
Jiahui Sun: Ocean University of China
Minghui Shi: Ocean University of China
Xinling Zhang: Ocean University of China
Xinzhi Lu: Ocean University of China
Feng Han: Ocean University of China
Qianhong Gong: Ocean University of China
Wengong Yu: Ocean University of China

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in the regulation of metabolism, stress responses, genome stability, and ageing. As a stress sensor, SIRT1 deacetylase activity is significantly increased during stresses, but the molecular mechanisms are not yet fully clear. Here, we show that SIRT1 is dynamically modified with O-GlcNAc at Ser 549 in its carboxy-terminal region, which directly increases its deacetylase activity both in vitro and in vivo. The O-GlcNAcylation of SIRT1 is elevated during genotoxic, oxidative, and metabolic stress stimuli in cellular and mouse models, thereby increasing SIRT1 deacetylase activity and protecting cells from stress-induced apoptosis. Our findings demonstrate a new mechanism for the activation of SIRT1 under stress conditions and suggest a novel potential therapeutic target for preventing age-related diseases and extending healthspan.

Date: 2017
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DOI: 10.1038/s41467-017-01654-6

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