Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses

Aránzazu Cruz-Adalia (), Guillermo Ramirez-Santiago, Jesús Osuna-Pérez, Mónica Torres-Torresano, Virgina Zorita, Ana Martínez-Riaño, Viola Boccasavia, Aldo Borroto, Gloria Martínez del Hoyo, José María González-Granado, Balbino Alarcón, Francisco Sánchez-Madrid and Esteban Veiga ()
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Aránzazu Cruz-Adalia: Centro Nacional de Biotecnología; Consejo Superior de Investigaciones Científicas (CNB-CSIC)
Guillermo Ramirez-Santiago: Centro Nacional de Biotecnología; Consejo Superior de Investigaciones Científicas (CNB-CSIC)
Jesús Osuna-Pérez: Centro Nacional de Biotecnología; Consejo Superior de Investigaciones Científicas (CNB-CSIC)
Mónica Torres-Torresano: Centro Nacional de Biotecnología; Consejo Superior de Investigaciones Científicas (CNB-CSIC)
Virgina Zorita: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Ana Martínez-Riaño: Centro de Biología Molecular Severo Ochoa (CBMSO); Nicolás Cabrera 1, Universidad Autónoma de Madrid
Viola Boccasavia: Centro de Biología Molecular Severo Ochoa (CBMSO); Nicolás Cabrera 1, Universidad Autónoma de Madrid
Aldo Borroto: Centro de Biología Molecular Severo Ochoa (CBMSO); Nicolás Cabrera 1, Universidad Autónoma de Madrid
Gloria Martínez del Hoyo: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
José María González-Granado: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Balbino Alarcón: Centro de Biología Molecular Severo Ochoa (CBMSO); Nicolás Cabrera 1, Universidad Autónoma de Madrid
Francisco Sánchez-Madrid: Instituto de Investigación Sanitaria Princesa
Esteban Veiga: Centro Nacional de Biotecnología; Consejo Superior de Investigaciones Científicas (CNB-CSIC)

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract Bacterial phagocytosis and antigen cross-presentation to activate CD8+ T cells are principal functions of professional antigen presenting cells. However, conventional CD4+ T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8+ T cells, which proliferate and become cytotoxic in response. CD4+ T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8+ T cells with low PD-1 expression. Moreover, transphagocytic CD4+ T cells induce protective anti-tumour immune responses by priming CD8+ T cells, highlighting the potential of CD4+ T cells as a tool for cancer immunotherapy.

Date: 2017
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DOI: 10.1038/s41467-017-01661-7

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