Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge

Jinsheng Wen, Annie Elong Ngono, Jose Angel Regla-Nava, Kenneth Kim, Matthew J. Gorman, Michael S. Diamond and Sujan Shresta ()
Additional contact information
Jinsheng Wen: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology
Annie Elong Ngono: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology
Jose Angel Regla-Nava: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology
Kenneth Kim: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology
Matthew J. Gorman: Washington University School of Medicine
Michael S. Diamond: Washington University School of Medicine
Sujan Shresta: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract Zika virus (ZIKV) and dengue virus (DENV) are antigenically related flaviviruses that share cross-reactivity in antibody and T cell responses, and co-circulate in increasing numbers of countries. Whether pre-existing DENV immunity can cross-protect or enhance ZIKV infection during sequential infection of the same host is unknown. Here, we show that DENV-immune Ifnar1 −/− or wild-type C57BL/6 mice infected with ZIKV have cross-reactive immunity to subsequent ZIKV infection and pathogenesis. Adoptive transfer and cell depletion studies demonstrate that DENV-immune CD8+ T cells predominantly mediate cross-protective responses to ZIKV. In contrast, passive transfer studies suggest that DENV-immune serum does not protect against ZIKV infection. Thus, CD8+ T cell immunity generated during primary DENV infection can confer protection against secondary ZIKV infection in mice. Further optimization of current DENV vaccines for T cell responses might confer cross-protection and prevent antibody-mediated enhancement of ZIKV infection.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-017-01669-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01669-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-017-01669-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().