Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment

Yanyun Gu, Xiaokai Wang, Junhua Li, Yifei Zhang, Huanzi Zhong, Ruixin Liu, Dongya Zhang, Qiang Feng, Xiaoyan Xie, Jie Hong, Huahui Ren, Wei Liu, Jing Ma, Qing Su, Hongmei Zhang, Jialin Yang, Xiaoling Wang, Xinjie Zhao, Weiqiong Gu, Yufang Bi, Yongde Peng, Xiaoqiang Xu, Huihua Xia, Fang Li, Xun Xu, Huanming Yang, Guowang Xu, Lise Madsen, Karsten Kristiansen (), Guang Ning () and Weiqing Wang ()
Additional contact information
Yanyun Gu: Shanghai Jiaotong University School of Medicine
Xiaokai Wang: China National GeneBank-Shenzhen
Junhua Li: China National GeneBank-Shenzhen
Yifei Zhang: Shanghai Jiaotong University School of Medicine
Huanzi Zhong: China National GeneBank-Shenzhen
Ruixin Liu: Shanghai Jiaotong University School of Medicine
Dongya Zhang: China National GeneBank-Shenzhen
Qiang Feng: China National GeneBank-Shenzhen
Xiaoyan Xie: Shanghai Jiaotong University School of Medicine
Jie Hong: Shanghai Jiaotong University School of Medicine
Huahui Ren: China National GeneBank-Shenzhen
Wei Liu: Renji Hospital affiliated to Shanghai Jiaotong University Medical School
Jing Ma: Renji Hospital affiliated to Shanghai Jiaotong University Medical School
Qing Su: Xinhua Hospital affiliated to Shanghai Jiaotong University Medical School
Hongmei Zhang: Xinhua Hospital affiliated to Shanghai Jiaotong University Medical School
Jialin Yang: MinHang Central Hospital affiliated to Fudan University Medical School
Xiaoling Wang: Chinese Academy of Science
Xinjie Zhao: Chinese Academy of Science
Weiqiong Gu: Shanghai Jiaotong University School of Medicine
Yufang Bi: Shanghai Jiaotong University School of Medicine
Yongde Peng: Shanghai Jiaotong University
Xiaoqiang Xu: China National GeneBank-Shenzhen
Huihua Xia: China National GeneBank-Shenzhen
Fang Li: China National GeneBank-Shenzhen
Xun Xu: China National GeneBank-Shenzhen
Huanming Yang: China National GeneBank-Shenzhen
Guowang Xu: Chinese Academy of Science
Lise Madsen: China National GeneBank-Shenzhen
Karsten Kristiansen: China National GeneBank-Shenzhen
Guang Ning: Shanghai Jiaotong University School of Medicine
Weiqing Wang: Shanghai Jiaotong University School of Medicine

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Antidiabetic medication may modulate the gut microbiota and thereby alter plasma and faecal bile acid (BA) composition, which may improve metabolic health. Here we show that treatment with Acarbose, but not Glipizide, increases the ratio between primary BAs and secondary BAs and plasma levels of unconjugated BAs in treatment-naive type 2 diabetes (T2D) patients, which may beneficially affect metabolism. Acarbose increases the relative abundances of Lactobacillus and Bifidobacterium in the gut microbiota and depletes Bacteroides, thereby changing the relative abundance of microbial genes involved in BA metabolism. Treatment outcomes of Acarbose are dependent on gut microbiota compositions prior to treatment. Compared to patients with a gut microbiota dominated by Prevotella, those with a high abundance of Bacteroides exhibit more changes in plasma BAs and greater improvement in metabolic parameters after Acarbose treatment. Our work highlights the potential for stratification of T2D patients based on their gut microbiota prior to treatment.

Date: 2017
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DOI: 10.1038/s41467-017-01682-2

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