Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy

Wei Chen, Rui Tian, Can Xu, Bryant C. Yung, Guohao Wang, Yijing Liu, Qianqian Ni, Fuwu Zhang, Zijian Zhou, Jingjing Wang, Gang Niu, Ying Ma, Liwu Fu () and Xiaoyuan Chen ()
Additional contact information
Wei Chen: Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Rui Tian: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Can Xu: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Bryant C. Yung: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Guohao Wang: Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Yijing Liu: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Qianqian Ni: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Fuwu Zhang: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Zijian Zhou: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Jingjing Wang: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Gang Niu: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Ying Ma: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Liwu Fu: Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Xiaoyuan Chen: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the consequent need for multiple daily injections that reduce patient compliance and increase treatment cost. In this study, we demonstrate a smart exendin-4 (Ex4) delivery device based on microneedle (MN)-array patches integrated with dual mineralized particles separately containing Ex4 and glucose oxidase (GOx). The dual mineralized particle-based system can specifically release Ex4 while immobilizing GOx as a result of the differential response to the microenvironment induced by biological stimuli. In this manner, the system enables glucose-responsive and closed-loop release to significantly improve Ex4 therapeutic performance. Moreover, integration of mineralized particles can enhance the mechanical strength of alginate-based MN by crosslinking to facilitate skin penetration, thus supporting painless and non-invasive transdermal administration. We believe this smart glucose-responsive Ex4 delivery holds great promise for type 2 diabetes therapy by providing safe, long-term, and on-demand Ex4 therapy.

Date: 2017
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DOI: 10.1038/s41467-017-01764-1

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