DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Yu-Hsiu Wang, Anushya Hariharan, Giulia Bastianello, Yusuke Toyama, G. V. Shivashankar, Marco Foiani and Michael P. Sheetz ()
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Yu-Hsiu Wang: National University of Singapore
Anushya Hariharan: National University of Singapore
Giulia Bastianello: the FIRC Institute of Molecular Oncology, Via Adamello
Yusuke Toyama: National University of Singapore
G. V. Shivashankar: National University of Singapore
Marco Foiani: the FIRC Institute of Molecular Oncology, Via Adamello
Michael P. Sheetz: National University of Singapore

Nature Communications, 2017, vol. 8, issue 1, 1-15

Abstract: Abstract Phosphoinositide lipids (PPIs) are enriched in the nucleus and are accumulated at DNA damage sites. Here, we investigate roles of nuclear PPIs in DNA damage response by sequestering specific PPIs with the expression of nuclear-targeted PH domains, which inhibits recruitment of Ataxia telangiectasia and Rad3-related protein (ATR) and reduces activation of Chk1. PPI-binding domains rapidly (

Date: 2017
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DOI: 10.1038/s41467-017-01805-9

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