Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes

Young-Ok Son, Seulki Park, Ji-Sun Kwak, Yoonkyung Won, Wan-Su Choi, Jinseol Rhee, Churl-Hong Chun, Je-Hwang Ryu, Don-Kyu Kim, Hueng-Sik Choi and Jang-Soo Chun ()
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Young-Ok Son: Gwangju Institute of Science and Technology
Seulki Park: Gwangju Institute of Science and Technology
Ji-Sun Kwak: Gwangju Institute of Science and Technology
Yoonkyung Won: Gwangju Institute of Science and Technology
Wan-Su Choi: Gwangju Institute of Science and Technology
Jinseol Rhee: Gwangju Institute of Science and Technology
Churl-Hong Chun: Wonkwang University School of Medicine
Je-Hwang Ryu: School of Dentistry, Chonnam National University
Don-Kyu Kim: Chonnam National University
Hueng-Sik Choi: Chonnam National University
Jang-Soo Chun: Gwangju Institute of Science and Technology

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract The estrogen-related receptor (ERR) family of orphan nuclear receptor is composed of ERRα, ERRβ, and ERRγ, which are known to regulate various isoform-specific functions under normal and pathophysiological conditions. Here, we investigate the involvement of ERRs in the pathogenesis of osteoarthritis (OA) in mice. Among ERR family members, ERRγ is markedly upregulated in cartilage from human OA patients and various mouse models of OA. Adenovirus-mediated overexpression of ERRγ in mouse knee joint or transgenic expression of ERRγ in cartilage leads to OA. ERRγ overexpression in chondrocytes directly upregulates matrix metalloproteinase (MMP)-3 and MMP13, which are known to play crucial roles in cartilage destruction in OA. In contrast, genetic ablation of Esrrg or shRNA-mediated downregulation of Esrrg in joint tissues abrogates experimental OA in mice. Our results collectively indicate that ERRγ is a novel catabolic regulator of OA pathogenesis.

Date: 2017
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DOI: 10.1038/s41467-017-01868-8

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