Plasma cell survival in the absence of B cell memory

Erika Hammarlund, Archana Thomas, Ian J. Amanna, Lindsay A. Holden, Ov D. Slayden, Byung Park, Lina Gao and Mark K. Slifka ()
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Erika Hammarlund: Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University
Archana Thomas: Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University
Ian J. Amanna: Najít Technologies, Inc
Lindsay A. Holden: Department of Biology, Portland State University
Ov D. Slayden: Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health & Science University
Byung Park: Biostatistics Shared Resource, Knight Cancer Institute
Lina Gao: Biostatistics Shared Resource, Knight Cancer Institute
Mark K. Slifka: Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract Pre-existing serum antibodies play an important role in vaccine-mediated protection against infection but the underlying mechanisms of immune memory are unclear. Clinical studies indicate that antigen-specific antibody responses can be maintained for many years, leading to theories that reactivation/differentiation of memory B cells into plasma cells is required to sustain long-term antibody production. Here, we present a decade-long study in which we demonstrate site-specific survival of bone marrow-derived plasma cells and durable antibody responses to multiple virus and vaccine antigens in rhesus macaques for years after sustained memory B cell depletion. Moreover, BrdU+ cells with plasma cell morphology can be detected for 10 years after vaccination/BrdU administration, indicating that plasma cells may persist for a prolonged period of time in the absence of cell division. On the basis of these results, long-lived plasma cells represent a key cell population responsible for long-term antibody production and serological memory.

Date: 2017
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DOI: 10.1038/s41467-017-01901-w

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