Transformation of the head-direction signal into a spatial code

Adrien Peyrache (), Natalie Schieferstein and Gyorgy Buzsáki ()
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Adrien Peyrache: Neuroscience Institute, School of Medicine
Natalie Schieferstein: Neuroscience Institute, School of Medicine
Gyorgy Buzsáki: Neuroscience Institute, School of Medicine

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract Animals integrate multiple sensory inputs to successfully navigate in their environments. Head direction (HD), boundary vector, grid and place cells in the entorhinal-hippocampal network form the brain’s navigational system that allows to identify the animal’s current location, but how the functions of these specialized neuron types are acquired remain to be understood. Here we report that activity of HD neurons is influenced by the ambulatory constraints imposed upon the animal by the boundaries of the explored environment, leading to spurious spatial information. However, in the post-subiculum, the main cortical stage of HD signal processing, HD neurons convey true spatial information in the form of border modulated activity through the integration of additional sensory modalities relative to egocentric position, unlike their driving thalamic inputs. These findings demonstrate how the combination of HD and egocentric information can be transduced into a spatial code.

Date: 2017
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DOI: 10.1038/s41467-017-01908-3

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