Intranasal infection and contact transmission of Zika virus in guinea pigs

Yong-Qiang Deng, Na-Na Zhang, Xiao-Feng Li, Ya-Qing Wang, Min Tian, Ye-Feng Qiu, Jun-Wan Fan, Jia-Nan Hao, Xing-Yao Huang, Hao-Long Dong, Hang Fan, Yu-Guang Wang, Fu-Chun Zhang, Yi-Gang Tong, Zhiheng Xu () and Cheng-Feng Qin ()
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Yong-Qiang Deng: Beijing Institute of Microbiology and Epidemiology
Na-Na Zhang: Beijing Institute of Microbiology and Epidemiology
Xiao-Feng Li: Beijing Institute of Microbiology and Epidemiology
Ya-Qing Wang: Chinese Academy of Sciences
Min Tian: Capital Medical University
Ye-Feng Qiu: Academy of Military Medical Science
Jun-Wan Fan: Chinese Academy of Sciences
Jia-Nan Hao: Beijing Institute of Microbiology and Epidemiology
Xing-Yao Huang: Beijing Institute of Microbiology and Epidemiology
Hao-Long Dong: Beijing Institute of Microbiology and Epidemiology
Hang Fan: State Key Laboratory of Pathogen and Biosecurity
Yu-Guang Wang: Capital Medical University
Fu-Chun Zhang: Guangzhou Medical University
Yi-Gang Tong: State Key Laboratory of Pathogen and Biosecurity
Zhiheng Xu: Chinese Academy of Sciences
Cheng-Feng Qin: Beijing Institute of Microbiology and Epidemiology

Nature Communications, 2017, vol. 8, issue 1, 1-8

Abstract: Abstract Zika virus (ZIKV) is primarily transmitted to humans through mosquito bites or sexual contact. The excretion and persistence of contagious ZIKV in various body fluids have been well documented in ZIKV patients; however, the risk of direct contact exposure remains unclear. Here, we show that guinea pigs are susceptible to ZIKV infection via subcutaneous inoculation route; infected guinea pigs exhibit seroconversion and significant viral secretion in sera, saliva, and tears. Notably, ZIKV is efficiently transmitted from infected guinea pigs to naïve co-caged animals. In particular, intranasal inoculation of ZIKV is fully capable of establishing infection in guinea pigs, and viral antigens are detected in multiple tissues including brain and parotid glands. Cynomolgus macaques also efficiently acquire ZIKV infection via intranasal and intragastric inoculation routes. These collective results from animal models highlight the risk of exposure to ZIKV contaminants and raise the possibility of close contact transmission of ZIKV in humans.

Date: 2017
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DOI: 10.1038/s41467-017-01923-4

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