Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus

Terkild Brink Buus (), Niels Ødum, Carsten Geisler and Jens Peter Holst Lauritsen
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Terkild Brink Buus: University of Copenhagen
Niels Ødum: University of Copenhagen
Carsten Geisler: University of Copenhagen
Jens Peter Holst Lauritsen: University of Copenhagen

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract Murine γδ T cells include subsets that are programmed for distinct effector functions during their development in the thymus. Under pathological conditions, different γδ T cell subsets can be protective or can exacerbate a disease. Here we show that CD117, CD200 and CD371, together with other markers, identify seven developmental stages of γδ T cells. These seven stages can be divided into three distinct developmental pathways that are enriched for different TCRδ repertoires and exhibit characteristic expression patterns associated with adaptive (γδTn), IFN-γ-producing (γδT1) and IFN-γ/IL-4-co-producing γδ T cells (γδNKT). Developmental progression towards both IFN-γ-producing subsets can be induced by TCR signalling, and each pathway results in thymic emigration at a different stage. Finally, we show that γδT1 cells are the predominating IFN-γ-producing subset developing in the adult thymus. Thus, this study maps out three distinct development pathways that result in the programming of γδTn, γδT1 and γδNKT cells.

Date: 2017
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DOI: 10.1038/s41467-017-01963-w

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