Alternative activation generates IL-10 producing type 2 innate lymphoid cells

Corey R. Seehus, Asha Kadavallore, Brian de la Torre, Alyson R. Yeckes, Yizhou Wang, Jie Tang and Jonathan Kaye ()
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Corey R. Seehus: Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Asha Kadavallore: Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Brian de la Torre: Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Alyson R. Yeckes: Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Yizhou Wang: Cedars-Sinai Medical Center
Jie Tang: Cedars-Sinai Medical Center
Jonathan Kaye: Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract Type 2 innate lymphoid cells (ILC2) share cytokine and transcription factor expression with CD4+ Th2 cells, but functional diversity of the ILC2 lineage has yet to be fully explored. Here, we show induction of a molecularly distinct subset of activated lung ILC2, termed ILC210. These cells produce IL-10 and downregulate some pro-inflammatory genes. Signals that generate ILC210 are distinct from those that induce IL-13 production, and gene expression data indicate that an alternative activation pathway leads to the generation of ILC210. In vivo, IL-2 enhances ILC210 generation and is associated with decreased eosinophil recruitment to the lung. Unlike most activated ILC2, the ILC210 population contracts after cessation of stimulation in vivo, with maintenance of a subset that can be recalled by restimulation, analogous to T-cell effector cell and memory cell generation. These data demonstrate the generation of a previously unappreciated IL-10 producing ILC2 effector cell population.

Date: 2017
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DOI: 10.1038/s41467-017-02023-z

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