High-resolution adaptive optical imaging within thick scattering media using closed-loop accumulation of single scattering

Sungsam Kang, Pilsung Kang, Seungwon Jeong, Yongwoo Kwon, Taeseok D. Yang, Jin Hee Hong, Moonseok Kim, Kyung–Deok Song, Jin Hyoung Park, Jun Ho Lee, Myoung Joon Kim, Ki Hean Kim and Wonshik Choi ()
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Sungsam Kang: Institute for Basic Science (IBS)
Pilsung Kang: Institute for Basic Science (IBS)
Seungwon Jeong: Institute for Basic Science (IBS)
Yongwoo Kwon: Institute for Basic Science (IBS)
Taeseok D. Yang: Institute for Basic Science (IBS)
Jin Hee Hong: Institute for Basic Science (IBS)
Moonseok Kim: Institute for Basic Science (IBS)
Kyung–Deok Song: Institute for Basic Science (IBS)
Jin Hyoung Park: Asan Medical Center
Jun Ho Lee: Pohang University of Science and Technology
Myoung Joon Kim: Asan Medical Center
Ki Hean Kim: Pohang University of Science and Technology
Wonshik Choi: Institute for Basic Science (IBS)

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract Thick biological tissues give rise to not only the multiple scattering of incoming light waves, but also the aberrations of remaining signal waves. The challenge for existing optical microscopy methods to overcome both problems simultaneously has limited sub-micron spatial resolution imaging to shallow depths. Here we present an optical coherence imaging method that can identify aberrations of waves incident to and reflected from the samples separately, and eliminate such aberrations even in the presence of multiple light scattering. The proposed method records the time-gated complex-field maps of backscattered waves over various illumination channels, and performs a closed-loop optimization of signal waves for both forward and phase-conjugation processes. We demonstrated the enhancement of the Strehl ratio by more than 500 times, an order of magnitude or more improvement over conventional adaptive optics, and achieved a spatial resolution of 600 nm up to an imaging depth of seven scattering mean free paths.

Date: 2017
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DOI: 10.1038/s41467-017-02117-8

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