Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate

Matthieu D. Lavigne, Dimitris Konstantopoulos, Katerina Z. Ntakou-Zamplara, Anastasios Liakos and Maria Fousteri ()
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Matthieu D. Lavigne: Biomedical Sciences Research Center ‘Alexander Fleming’
Dimitris Konstantopoulos: Biomedical Sciences Research Center ‘Alexander Fleming’
Katerina Z. Ntakou-Zamplara: Biomedical Sciences Research Center ‘Alexander Fleming’
Anastasios Liakos: Biomedical Sciences Research Center ‘Alexander Fleming’
Maria Fousteri: Biomedical Sciences Research Center ‘Alexander Fleming’

Nature Communications, 2017, vol. 8, issue 1, 1-15

Abstract: Abstract Complex molecular responses preserve gene expression accuracy and genome integrity in the face of environmental perturbations. Here we report that, in response to UV irradiation, RNA polymerase II (RNAPII) molecules are dynamically and synchronously released from promoter-proximal regions into elongation to promote uniform and accelerated surveillance of the whole transcribed genome. The maximised influx of de novo released RNAPII correlates with increased damage-sensing, as confirmed by RNAPII progressive accumulation at dipyrimidine sites and by the average slow-down of elongation rates in gene bodies. In turn, this transcription elongation ‘safe’ mode guarantees efficient DNA repair regardless of damage location, gene size and transcription level. Accordingly, we detect low and homogenous rates of mutational signatures associated with UV exposure or cigarette smoke across all active genes. Our study reveals a novel advantage for transcription regulation at the promoter-proximal level and provides unanticipated insights into how active transcription shapes the mutagenic landscape of cancer genomes.

Date: 2017
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DOI: 10.1038/s41467-017-02145-4

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