Metas-Chip precisely identifies presence of micrometastasis in live biopsy samples by label free approach

Mohammad Saeid Nikshoar, Mohammad Ali Khayamian, Saeid Ansaryan, Hassan Sanati, Milad Gharooni, Leila Farahmand, Farshad Rezakhanloo, Keivan Majidzadeh-A, Parisa Hoseinpour, Shahrzad Dadgari, Leila Kiani-M, Mohammad Saqafi, Masoumeh Gity and Mohammad Abdolahad ()
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Mohammad Saeid Nikshoar: University of Tehran
Mohammad Ali Khayamian: University of Tehran
Saeid Ansaryan: University of Tehran
Hassan Sanati: ACECR
Milad Gharooni: University of Tehran
Leila Farahmand: ACECR
Farshad Rezakhanloo: University of Tehran
Keivan Majidzadeh-A: ACECR
Parisa Hoseinpour: ACECR
Shahrzad Dadgari: ACECR
Leila Kiani-M: ACECR
Mohammad Saqafi: University of Tehran
Masoumeh Gity: Tehran University of Medical Sciences
Mohammad Abdolahad: University of Tehran

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract Detecting the micrometastasis is a major challenge in patients’ survival. The small volume of the biopsied tissue results in limited number of histopathological samples and might reduce the rate of accurate diagnosis even by molecular technologies. We introduce a microelectronic biochip (named Metas-Chip) to detect the micrometastasis in unprocessed liquid or solid samples. It works based on the tendency of malignant cells to track single human umbilical vein endothelial cell (HUVEC)-sensing traps. Such cells detach themselves from the biopsied sample and invade the sensing traps by inducing membrane retraction and blebbing, which result in sharp changes in electrical response of the sensing elements. Metas-Chip identified the metastasis in more than 70 breast cancer patients, in less than 5 h. Moreover it detected the metastasis in lymph nodes of nine patients whom were missed by conventional pathological procedure. Multilevel IHC and real-time polymerase chain reaction (RT-PCR) tests confirmed the diagnosis.

Date: 2017
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DOI: 10.1038/s41467-017-02184-x

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