Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques

Dawn M. Dudley, Christina M. Newman, Joseph Lalli, Laurel M. Stewart, Michelle R. Koenig, Andrea M. Weiler, Matthew R. Semler, Gabrielle L. Barry, Katie R. Zarbock, Mariel S. Mohns, Meghan E. Breitbach, Nancy Schultz-Darken, Eric Peterson, Wendy Newton, Emma L. Mohr, Saverio Capuano, Jorge E. Osorio, Shelby L. O’Connor, David H. O’Connor, Thomas C. Friedrich and Matthew T. Aliota ()
Additional contact information
Dawn M. Dudley: University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
Christina M. Newman: University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
Joseph Lalli: University of Wisconsin-Madison School of Veterinary Medicine, 1656 Linden Dr.
Laurel M. Stewart: University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
Michelle R. Koenig: University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
Andrea M. Weiler: University of Wisconsin-Madison, 1220 Capitol Ct.
Matthew R. Semler: University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
Gabrielle L. Barry: University of Wisconsin-Madison, 1220 Capitol Ct.
Katie R. Zarbock: University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
Mariel S. Mohns: University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
Meghan E. Breitbach: University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
Nancy Schultz-Darken: University of Wisconsin-Madison, 1220 Capitol Ct.
Eric Peterson: University of Wisconsin-Madison, 1220 Capitol Ct.
Wendy Newton: University of Wisconsin-Madison, 1220 Capitol Ct.
Emma L. Mohr: University of Wisconsin-Madison, University of Wisconsin Clinical Science Center, 600 Highland Ave
Saverio Capuano: University of Wisconsin-Madison, 1220 Capitol Ct.
Jorge E. Osorio: University of Wisconsin-Madison School of Veterinary Medicine, 1656 Linden Dr.
Shelby L. O’Connor: University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
David H. O’Connor: University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.
Thomas C. Friedrich: University of Wisconsin-Madison School of Veterinary Medicine, 1656 Linden Dr.
Matthew T. Aliota: University of Wisconsin-Madison School of Veterinary Medicine, 1656 Linden Dr.

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract Mouse and nonhuman primate models now serve as useful platforms to study Zika virus (ZIKV) pathogenesis, candidate therapies, and vaccines, but they rely on needle inoculation of virus: the effects of mosquito-borne infection on disease outcome have not been explored in these models. Here we show that infection via mosquito bite delays ZIKV replication to peak viral loads in rhesus macaques. Importantly, in mosquito-infected animals ZIKV tissue distribution was limited to hemolymphatic tissues, female reproductive tract tissues, kidney, and liver, potentially emulating key features of human ZIKV infections, most of which are characterized by mild or asymptomatic disease. Furthermore, deep sequencing analysis reveals that ZIKV populations in mosquito-infected monkeys show greater sequence heterogeneity and lower overall diversity than in needle-inoculated animals. This newly developed system will be valuable for studying ZIKV disease because it more closely mimics human infection by mosquito bite than needle-based inoculations.

Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-017-02222-8 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-02222-8

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-017-02222-8

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().