The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation

Meng Du, Lin Yuan, Xin Tan, Dandan Huang, Xiaojing Wang, Zhe Zheng, Xiaoxiang Mao, Xiangrao Li, Liu Yang, Kun Huang, Fengxiao Zhang, Yan Wang, Xi Luo, Dan Huang and Kai Huang ()
Additional contact information
Meng Du: Huazhong University of Science and Technology
Lin Yuan: Huazhong University of Science and Technology
Xin Tan: Huazhong University of Science and Technology
Dandan Huang: Huazhong University of Science and Technology
Xiaojing Wang: Huazhong University of Science and Technology
Zhe Zheng: Huazhong University of Science and Technology
Xiaoxiang Mao: Huazhong University of Science and Technology
Xiangrao Li: Huazhong University of Science and Technology
Liu Yang: Huazhong University of Science and Technology
Kun Huang: Huazhong University of Science and Technology
Fengxiao Zhang: Huazhong University of Science and Technology
Yan Wang: Huazhong University of Science and Technology
Xi Luo: Huazhong University of Science and Technology
Dan Huang: Huazhong University of Science and Technology
Kai Huang: Huazhong University of Science and Technology

Nature Communications, 2017, vol. 8, issue 1, 1-18

Abstract: Abstract Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRR) with a crucial function in innate immune responses. Activation of TLR4 signaling at the plasma membrane by lipopolysaccharide (LPS) stimulates proinflammatory signaling pathways dependent on the E3 ubiquitin ligase TRAF6. Here we show the LPS-induced long non-coding RNA (lncRNA) Mirt2 functions as a checkpoint to prevent aberrant activation of inflammation, and is a potential regulator of macrophage polarization. Mirt2 associates with, and attenuates Lys63 (K63)-linked ubiquitination of, TRAF6, thus inhibiting activation of NF-κB and MAPK pathways and limiting production of proinflammatory cytokines. Adenovirus mediated gene transfer of Mirt2 protects mice from endotoxemia induced fatality and multi-organ dysfunction. These findings identify lncRNA Mirt2 as a negative feedback regulator of excessive inflammation.

Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-017-02229-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-02229-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-017-02229-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().