An oomycete plant pathogen reprograms host pre-mRNA splicing to subvert immunity

Jie Huang, Lianfeng Gu, Ying Zhang, Tingxiu Yan, Guanghui Kong, Liang Kong, Baodian Guo, Min Qiu, Yang Wang, Maofeng Jing, Weiman Xing, Wenwu Ye, Zhe Wu, Zhengguang Zhang, Xiaobo Zheng, Mark Gijzen, Yuanchao Wang and Suomeng Dong ()
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Jie Huang: Nanjing Agricultural University
Lianfeng Gu: Fujian Agriculture and Forestry University
Ying Zhang: Nanjing Agricultural University
Tingxiu Yan: Nanjing Agricultural University
Guanghui Kong: Nanjing Agricultural University
Liang Kong: Nanjing Agricultural University
Baodian Guo: Nanjing Agricultural University
Min Qiu: Nanjing Agricultural University
Yang Wang: Nanjing Agricultural University
Maofeng Jing: Nanjing Agricultural University
Weiman Xing: Chinese Academy of Sciences
Wenwu Ye: Nanjing Agricultural University
Zhe Wu: South University of Science and Technology of China, Shenzhen
Zhengguang Zhang: Nanjing Agricultural University
Xiaobo Zheng: Nanjing Agricultural University
Mark Gijzen: Agriculture and Agri-Food Canada
Yuanchao Wang: Nanjing Agricultural University
Suomeng Dong: Nanjing Agricultural University

Nature Communications, 2017, vol. 8, issue 1, 1-15

Abstract: Abstract The process of RNA splicing influences many physiological processes, including plant immunity. However, how plant parasites manipulate host RNA splicing process remains unknown. Here we demonstrate that PsAvr3c, an avirulence effector from oomycete plant pathogen Phytophthora sojae, physically binds to and stabilizes soybean serine/lysine/arginine-rich proteins GmSKRPs. The SKRPs are novel proteins that associate with a complex that contains plant spliceosome components, and are negative regulators of plant immunity. Analysis by RNA-seq data indicates that alternative splicing of pre-mRNAs from 401 soybean genes, including defense-related genes, is altered in GmSKRP1 and PsAvr3c overexpressing lines compared to control plants. Representative splicing events mediated by GmSKRP1 and PsAvr3c are tested by infection assays or by transient expression in soybean plants. Our results show that plant pathogen effectors can reprogram host pre-mRNA splicing to promote disease, and we propose that pathogens evolved such strategies to defeat host immune systems.

Date: 2017
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DOI: 10.1038/s41467-017-02233-5

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