Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses

Minh-Thu Nguyen, Julia Uebele, Nimerta Kumari, Hiroshi Nakayama, Lena Peter, Olga Ticha, Anne-Kathrin Woischnig, Mathias Schmaler, Nina Khanna, Naoshi Dohmae, Bok Luel Lee, Isabelle Bekeredjian-Ding and Friedrich Götz ()
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Minh-Thu Nguyen: University of Tübingen
Julia Uebele: Federal Regulatory Agency for Vaccines and Biomedicines
Nimerta Kumari: University of Tübingen
Hiroshi Nakayama: RIKEN Center for Sustainable Resource Science
Lena Peter: Federal Regulatory Agency for Vaccines and Biomedicines
Olga Ticha: Federal Regulatory Agency for Vaccines and Biomedicines
Anne-Kathrin Woischnig: University Hospital Basel
Mathias Schmaler: University Hospital Basel
Nina Khanna: University Hospital Basel
Naoshi Dohmae: RIKEN Center for Sustainable Resource Science
Bok Luel Lee: Pusan National University
Isabelle Bekeredjian-Ding: Federal Regulatory Agency for Vaccines and Biomedicines
Friedrich Götz: University of Tübingen

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Lipoproteins (Lpp) of Gram-positive bacteria are major players in alerting our immune system. Here, we show that the TLR2 response induced by commensal species Staphylococcus aureus and Staphylococcus epidermidis is almost ten times lower than that induced by noncommensal Staphylococcus carnosus, and this is at least partially due to their different modifications of the Lpp lipid moieties. The N terminus of the lipid moiety is acylated with a long-chain fatty acid (C17) in S. aureus and S. epidermidis, while it is acylated with a short-chain fatty acid (C2) in S. carnosus. The long-chain N-acylated Lpp, recognized by TLR2–TLR1 receptors, silences innate and adaptive immune responses, while the short-chain N-acetylated Lpp, recognized by TLR2–TLR6 receptors, boosts it.

Date: 2017
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DOI: 10.1038/s41467-017-02234-4

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