Stochastic gene expression in Arabidopsis thaliana

Ilka Schultheiß Araújo, Jessica Magdalena Pietsch, Emma Mathilde Keizer, Bettina Greese, Rachappa Balkunde, Christian Fleck () and Martin Hülskamp ()
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Ilka Schultheiß Araújo: Cologne University
Jessica Magdalena Pietsch: Cologne University
Emma Mathilde Keizer: Wageningen University
Bettina Greese: Faculty for Theoretical Physics and Astronomy, Lund University
Rachappa Balkunde: Cologne University
Christian Fleck: Wageningen University
Martin Hülskamp: Cologne University

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract Although plant development is highly reproducible, some stochasticity exists. This developmental stochasticity may be caused by noisy gene expression. Here we analyze the fluctuation of protein expression in Arabidopsis thaliana. Using the photoconvertible KikGR marker, we show that the protein expressions of individual cells fluctuate over time. A dual reporter system was used to study extrinsic and intrinsic noise of marker gene expression. We report that extrinsic noise is higher than intrinsic noise and that extrinsic noise in stomata is clearly lower in comparison to several other tissues/cell types. Finally, we show that cells are coupled with respect to stochastic protein expression in young leaves, hypocotyls and roots but not in mature leaves. Our data indicate that stochasticity of gene expression can vary between tissues/cell types and that it can be coupled in a non-cell-autonomous manner.

Date: 2017
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DOI: 10.1038/s41467-017-02285-7

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