The interhemispheric CA1 circuit governs rapid generalisation but not fear memory

Heng Zhou, Gui-Jing Xiong, Liang Jing, Ning-Ning Song, Pu De-Lin, Xun Tang, Xiao-Bing He, Fu-Qiang Xu, Jing-Fei Huang, Ling-Jiang Li, Gal Richter-Levin, Rong-Rong Mao, Qi-Xin Zhou (), Yu-Qiang Ding () and Lin Xu ()
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Heng Zhou: The Chinese Academy of Sciences
Gui-Jing Xiong: The Chinese Academy of Sciences
Liang Jing: The Chinese Academy of Sciences
Ning-Ning Song: Tongji University School of Medicine
Pu De-Lin: The Chinese Academy of Sciences
Xun Tang: University of Science and Technology of China
Xiao-Bing He: The Chinese Academy of Sciences
Fu-Qiang Xu: The Chinese Academy of Sciences
Jing-Fei Huang: The Chinese Academy of Sciences
Ling-Jiang Li: Second Xiangya Hospital of Central South University
Gal Richter-Levin: University of Haifa
Rong-Rong Mao: The Chinese Academy of Sciences
Qi-Xin Zhou: The Chinese Academy of Sciences
Yu-Qiang Ding: Tongji University School of Medicine
Lin Xu: The Chinese Academy of Sciences

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract Encoding specificity theory predicts most effective recall by the original conditions at encoding, while generalization endows recall flexibly under circumstances which deviate from the originals. The CA1 regions have been implicated in memory and generalization but whether and which locally separated mechanisms are involved is not clear. We report here that fear memory is quickly formed, but generalization develops gradually over 24 h. Generalization but not fear memory is impaired by inhibiting ipsilateral (ips) or contralateral (con) CA1, and by optogenetic silencing of the ipsCA1 projections onto conCA1. By contrast, in vivo fEPSP recordings reveal that ipsCA1–conCA1 synaptic efficacy is increased with delay over 24 h when generalization is formed but it is unchanged if generalization is disrupted. Direct excitation of ipsCA1–conCA1 synapses using chemogenetic hM3Dq facilitates generalization formation. Thus, rapid generalization is an active process dependent on bilateral CA1 regions, and encoded by gradual synaptic learning in ipsCA1–conCA1 circuit.

Date: 2017
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DOI: 10.1038/s41467-017-02315-4

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