The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy

Dan A. Landau, Clare Sun, Daniel Rosebrock, Sarah E. M. Herman, Joshua Fein, Mariela Sivina, Chingiz Underbayev, Delong Liu, Julia Hoellenriegel, Sarangan Ravichandran, Mohammed Z. H. Farooqui, Wandi Zhang, Carrie Cibulskis, Asaf Zviran, Donna S. Neuberg, Dimitri Livitz, Ivana Bozic, Ignaty Leshchiner, Gad Getz, Jan A. Burger, Adrian Wiestner () and Catherine J. Wu ()
Additional contact information
Dan A. Landau: New York Genome Center
Clare Sun: National Institutes of Health
Daniel Rosebrock: Broad Institute
Sarah E. M. Herman: National Institutes of Health
Joshua Fein: New York Genome Center
Mariela Sivina: The University of Texas MD Anderson Cancer Center
Chingiz Underbayev: National Institutes of Health
Delong Liu: National Institutes of Health
Julia Hoellenriegel: The University of Texas MD Anderson Cancer Center
Sarangan Ravichandran: Leidos Biomedical Research Inc
Mohammed Z. H. Farooqui: National Institutes of Health
Wandi Zhang: Dana-Farber Cancer Institute
Carrie Cibulskis: Broad Institute
Asaf Zviran: New York Genome Center
Donna S. Neuberg: Dana-Farber Cancer Institute
Dimitri Livitz: Broad Institute
Ivana Bozic: University of Washington
Ignaty Leshchiner: Broad Institute
Gad Getz: Broad Institute
Jan A. Burger: The University of Texas MD Anderson Cancer Center
Adrian Wiestner: National Institutes of Health
Catherine J. Wu: Broad Institute

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Treatment of chronic lymphocytic leukemia (CLL) has shifted from chemo-immunotherapy to targeted agents. To define the evolutionary dynamics induced by targeted therapy in CLL, we perform serial exome and transcriptome sequencing for 61 ibrutinib-treated CLLs. Here, we report clonal shifts (change >0.1 in clonal cancer cell fraction, Q

Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-017-02329-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-02329-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-017-02329-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().