The F-box protein FKF1 inhibits dimerization of COP1 in the control of photoperiodic flowering

Byoung-Doo Lee, Mi Ri Kim, Min-Young Kang, Joon-Yung Cha, Su-Hyun Han, Ganesh M. Nawkar, Yasuhito Sakuraba, Sang Yeol Lee, Takato Imaizumi, C. Robertson McClung, Woe-Yeon Kim () and Nam-Chon Paek ()
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Byoung-Doo Lee: Seoul National University
Mi Ri Kim: Gyeongsang National University
Min-Young Kang: Seoul National University
Joon-Yung Cha: Gyeongsang National University
Su-Hyun Han: Seoul National University
Ganesh M. Nawkar: Gyeongsang National University
Yasuhito Sakuraba: Seoul National University
Sang Yeol Lee: Gyeongsang National University
Takato Imaizumi: University of Washington
C. Robertson McClung: Dartmouth College
Woe-Yeon Kim: Gyeongsang National University
Nam-Chon Paek: Seoul National University

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract In Arabidopsis thaliana, CONSTANS (CO) plays an essential role in the regulation of photoperiodic flowering under long-day conditions. CO protein is stable only in the afternoon of long days, when it induces the expression of FLOWERING LOCUS T (FT), which promotes flowering. The blue-light photoreceptor FLAVIN-BINDING, KELCH REPEAT, F-BOX1 (FKF1) interacts with CO and stabilizes it by an unknown mechanism. Here, we provide genetic and biochemical evidence that FKF1 inhibits CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1)-dependent CO degradation. Light-activated FKF1 has no apparent effect on COP1 stability but can interact with and negatively regulate COP1. We show that FKF1 can inhibit COP1 homo-dimerization. Mutation of the coiled-coil domain in COP1, which prevents dimer formation, impairs COP1 function in coordinating flowering time. Based on these results, we propose a model whereby the light- and day length-dependent interaction between FKF1 and COP1 controls CO stability to regulate flowering time.

Date: 2017
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DOI: 10.1038/s41467-017-02476-2

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