Ultrasensitive reversible chromophore reaction of BODIPY functions as high ratio double turn on probe

Dehui Hu (), Tao Zhang, Shayu Li, Tianjun Yu, Xiaohui Zhang, Rui Hu, Jiao Feng, Shuangqing Wang, Tongling Liang, Jianming Chen, Lyubov N. Sobenina, Boris A. Trofimov (), Yi Li, Jinshi Ma and Guoqiang Yang ()
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Dehui Hu: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Tao Zhang: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Shayu Li: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Tianjun Yu: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Xiaohui Zhang: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Rui Hu: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Jiao Feng: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Shuangqing Wang: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Tongling Liang: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Jianming Chen: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Lyubov N. Sobenina: Siberian Branch of the Russian Academy of Sciences
Boris A. Trofimov: Siberian Branch of the Russian Academy of Sciences
Yi Li: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Jinshi Ma: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Guoqiang Yang: University of Chinese Academy of Sciences, Chinese Academy of Sciences

Nature Communications, 2018, vol. 9, issue 1, 1-10

Abstract: Abstract Chromophore reactions with changes to conjugation degree, especially those between the conjugated and unconjugated state, will bring a large spectral variation. To realize such a process, a meso-naked BODIPY (MNBOD) with two electron-withdrawing groups around the core is designed and synthesized. The resulting system is extremely sensitive to bases. The red, highly fluorescent solution readily becomes colorless and non-fluorescent after base addition; however, the color and fluorescence can be totally and instantly restored by addition of acid or formaldehyde. Analyses show that two identical MNBODs are connected by a C–C single bond (sp3) at the meso-position through a radical reaction that results in an unconjugated, colorless dimer complexed with bases. When the bases are consumed, the dimer immediately dissociates into the red, highly fluorescent, conjugated MNBOD monomer. With 260 nm spectral change and over 120,000 turn-on ratio, this chromophore-reaction can be utilized as a sensitive reaction-based dual-signal probe.

Date: 2018
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DOI: 10.1038/s41467-017-02270-0

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