LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription

Cui-Yun Liu, Yu-Hui Zhang, Rui-Bei Li, Lu-Yu Zhou, Tao An, Rong-Cheng Zhang, Mei Zhai, Yan Huang, Kao-Wen Yan, Yan-Han Dong, Murugavel Ponnusamy, Chan Shan, Sheng Xu, Qi Wang, Yan-Hui Zhang, Jian Zhang and Kun Wang ()
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Cui-Yun Liu: Institute for Translational Medicine, College of Medicine, Qingdao University
Yu-Hui Zhang: Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College
Rui-Bei Li: Northwestern University
Lu-Yu Zhou: Institute for Translational Medicine, College of Medicine, Qingdao University
Tao An: Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College
Rong-Cheng Zhang: Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College
Mei Zhai: Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College
Yan Huang: Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College
Kao-Wen Yan: Institute for Translational Medicine, College of Medicine, Qingdao University
Yan-Han Dong: Institute for Translational Medicine, College of Medicine, Qingdao University
Murugavel Ponnusamy: Institute for Translational Medicine, College of Medicine, Qingdao University
Chan Shan: Institute for Translational Medicine, College of Medicine, Qingdao University
Sheng Xu: Institute for Translational Medicine, College of Medicine, Qingdao University
Qi Wang: Institute for Translational Medicine, College of Medicine, Qingdao University
Yan-Hui Zhang: Institute for Translational Medicine, College of Medicine, Qingdao University
Jian Zhang: Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College
Kun Wang: Institute for Translational Medicine, College of Medicine, Qingdao University

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Increasing evidence suggests that long noncoding RNAs (lncRNAs) play crucial roles in various biological processes. However, little is known about the effects of lncRNAs on autophagy. Here we report that a lncRNA, termed cardiac autophagy inhibitory factor (CAIF), suppresses cardiac autophagy and attenuates myocardial infarction by targeting p53-mediated myocardin transcription. Myocardin expression is upregulated upon H2O2 and ischemia/reperfusion, and knockdown of myocardin inhibits autophagy and attenuates myocardial infarction. p53 regulates cardiomyocytes autophagy and myocardial ischemia/reperfusion injury by regulating myocardin expression. CAIF directly binds to p53 protein and blocks p53-mediated myocardin transcription, which results in the decrease of myocardin expression. Collectively, our data reveal a novel CAIF-p53-myocardin axis as a critical regulator in cardiomyocyte autophagy, which will be potential therapeutic targets in treatment of defective autophagy-associated cardiovascular diseases.

Date: 2018
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DOI: 10.1038/s41467-017-02280-y

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