Role of outer surface probes for regulating ion gating of nanochannels

Xinchun Li, Tianyou Zhai, Pengcheng Gao, Hongli Cheng, Ruizuo Hou, Xiaoding Lou and Fan Xia ()
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Xinchun Li: Huazhong University of Science and Technology (HUST)
Tianyou Zhai: Huazhong University of Science and Technology (HUST)
Pengcheng Gao: China University of Geosciences
Hongli Cheng: Huazhong University of Science and Technology (HUST)
Ruizuo Hou: Huazhong University of Science and Technology (HUST)
Xiaoding Lou: Huazhong University of Science and Technology (HUST)
Fan Xia: Huazhong University of Science and Technology (HUST)

Nature Communications, 2018, vol. 9, issue 1, 1-10

Abstract: Abstract Nanochannels with functional elements have shown promise for DNA sequencing, single-molecule sensing, and ion gating. Ionic current measurement is currently a benchmark, but is focused solely on the contribution from nanochannels’ inner-wall functional elements (NIWFE); the attributes of functional elements at nanochannels’ outer surface (NOSFE) are nearly ignored, and remain elusive. Here we show that the role of NOSFE and NIWFE for ion gating can be distinguished by constructing DNA architectures using dual-current readout. The established molecular switches have continuously tunable and reversible ion-gating ability. We find that NOSFE exhibits negligible ion-gating behavior, but it can produce a synergistic effect in alliance with NIWFE. Moreover, the high-efficiency gating systems display more noticeable synergistic effect than the low-efficiency ones. We also reveal that the probe amount of NOSFE and NIWFE is almost equally distributed in our biomimetic nanochannels, which is potentially a premise for the synergistic ion-gating phenomena.

Date: 2018
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DOI: 10.1038/s41467-017-02447-7

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