Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota

Aurélie Durand, Alexandra Audemard-Verger, Vincent Guichard, Raphaël Mattiuz, Arnaud Delpoux, Pauline Hamon, Nelly Bonilla, Matthieu Rivière, Jérôme Delon, Bruno Martin, Cédric Auffray, Alexandre Boissonnas and Bruno Lucas ()
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Aurélie Durand: CNRS UMR8104, INSERM U1016
Alexandra Audemard-Verger: CNRS UMR8104, INSERM U1016
Vincent Guichard: CNRS UMR8104, INSERM U1016
Raphaël Mattiuz: CNRS UMR8104, INSERM U1016
Arnaud Delpoux: CNRS UMR8104, INSERM U1016
Pauline Hamon: Centre d’Immunologie et des Maladies Infectieuses
Nelly Bonilla: CNRS UMR8104, INSERM U1016
Matthieu Rivière: CNRS UMR8104, INSERM U1016
Jérôme Delon: CNRS UMR8104, INSERM U1016
Bruno Martin: CNRS UMR8104, INSERM U1016
Cédric Auffray: CNRS UMR8104, INSERM U1016
Alexandre Boissonnas: Centre d’Immunologie et des Maladies Infectieuses
Bruno Lucas: CNRS UMR8104, INSERM U1016

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed characterization of this lymphoid-resident T cell pool has not yet been done. Here we show that a substantial proportion of CD4 regulatory (Treg) and memory (Tmem) cells establish long-term residence in the SLOs of specific pathogen-free mice. Of these SLOs, only T cell residence within Peyer’s patches is affected by microbiota. Resident CD4 Treg and CD4 Tmem cells from lymph nodes and non-lymphoid tissues share many phenotypic and functional characteristics. The percentage of resident T cells in SLOs increases considerably with age, with S1PR1 downregulation possibly contributing to this altered homeostasis. Our results thus show that T cell residence is not only a hallmark of non-lymphoid tissues, but can be extended to secondary lymphoid organs.

Date: 2018
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DOI: 10.1038/s41467-017-02458-4

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