Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task

Takahide Itokazu, Masashi Hasegawa, Rui Kimura, Hironobu Osaki, Urban-Raphael Albrecht, Kazuhiro Sohya, Shubhodeep Chakrabarti, Hideaki Itoh, Tetsufumi Ito, Tatsuo K. Sato () and Takashi R. Sato ()
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Takahide Itokazu: University of Tübingen
Masashi Hasegawa: University of Tübingen
Rui Kimura: University of Tübingen
Hironobu Osaki: University of Tübingen
Urban-Raphael Albrecht: University of Tübingen
Kazuhiro Sohya: National Center of Neurology and Psychiatry
Shubhodeep Chakrabarti: University of Tübingen
Hideaki Itoh: Saga University
Tetsufumi Ito: Kanazawa Medical University
Tatsuo K. Sato: University of Tübingen
Takashi R. Sato: University of Tübingen

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Cortical computation is distributed across multiple areas of the cortex by networks of reciprocal connectivity. However, how such connectivity contributes to the communication between the connected areas is not clear. In this study, we examine the communication between sensory and motor cortices. We develop an eye movement task in mice and combine it with optogenetic suppression and two-photon calcium imaging techniques. We identify a small region in the secondary motor cortex (MOs) that controls eye movements and reciprocally connects with a rostrolateral part of the higher visual areas (VRL/A/AL). These two regions encode both motor signals and visual information; however, the information flow between the regions depends on the direction of the connectivity: motor information is conveyed preferentially from the MOs to the VRL/A/AL, and sensory information is transferred primarily in the opposite direction. We propose that reciprocal connectivity streamlines information flow, enhancing the computational capacity of a distributed network.

Date: 2018
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DOI: 10.1038/s41467-017-02501-4

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