Maturation of the gut microbiome and risk of asthma in childhood

Jakob Stokholm, Martin J. Blaser, Jonathan Thorsen, Morten A. Rasmussen, Johannes Waage, Rebecca K. Vinding, Ann-Marie M. Schoos, Asja Kunøe, Nadia R. Fink, Bo L. Chawes, Klaus Bønnelykke, Asker D. Brejnrod, Martin S. Mortensen, Waleed Abu Al-Soud, Søren J. Sørensen () and Hans Bisgaard ()
Additional contact information
Jakob Stokholm: University of Copenhagen
Martin J. Blaser: New York University Langone Medical Center
Jonathan Thorsen: University of Copenhagen
Morten A. Rasmussen: University of Copenhagen
Johannes Waage: University of Copenhagen
Rebecca K. Vinding: University of Copenhagen
Ann-Marie M. Schoos: University of Copenhagen
Asja Kunøe: University of Copenhagen
Nadia R. Fink: University of Copenhagen
Bo L. Chawes: University of Copenhagen
Klaus Bønnelykke: University of Copenhagen
Asker D. Brejnrod: University of Copenhagen
Martin S. Mortensen: University of Copenhagen
Waleed Abu Al-Soud: University of Copenhagen
Søren J. Sørensen: University of Copenhagen
Hans Bisgaard: University of Copenhagen

Nature Communications, 2018, vol. 9, issue 1, 1-10

Abstract: Abstract The composition of the human gut microbiome matures within the first years of life. It has been hypothesized that microbial compositions in this period can cause immune dysregulations and potentially cause asthma. Here we show, by associating gut microbial composition from 16S rRNA gene amplicon sequencing during the first year of life with subsequent risk of asthma in 690 participants, that 1-year-old children with an immature microbial composition have an increased risk of asthma at age 5 years. This association is only apparent among children born to asthmatic mothers, suggesting that lacking microbial stimulation during the first year of life can trigger their inherited asthma risk. Conversely, adequate maturation of the gut microbiome in this period may protect these pre-disposed children.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02573-2

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DOI: 10.1038/s41467-017-02573-2

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