Nanoparticle elasticity directs tumor uptake

Peng Guo, Daxing Liu, Kriti Subramanyam, Biran Wang, Jiang Yang, Jing Huang, Debra T. Auguste () and Marsha A. Moses ()
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Peng Guo: Boston Children’s Hospital
Daxing Liu: The City College of New York
Kriti Subramanyam: Boston Children’s Hospital
Biran Wang: The City College of New York
Jiang Yang: Boston Children’s Hospital
Jing Huang: Boston Children’s Hospital
Debra T. Auguste: The City College of New York
Marsha A. Moses: Boston Children’s Hospital

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract To date, the role of elasticity in drug delivery remains elusive due to the inability to measure microscale mechanics and alter rheology without affecting chemistry. Herein, we describe the in vitro cellular uptake and in vivo tumor uptake of nanolipogels (NLGs). NLGs are composed of identical lipid bilayers encapsulating an alginate core, with tunable elasticity. The elasticity of NLGs was evaluated by atomic force microscopy, which demonstrated that they exhibit Young’s moduli ranging from 45 ± 9 to 19,000 ± 5 kPa. Neoplastic and non-neoplastic cells exhibited significantly greater uptake of soft NLGs (Young’s modulus 13.8 MPa). In an orthotopic breast tumor model, soft NLGs accumulated significantly more in tumors, whereas elastic NLGs preferentially accumulated in the liver. Our findings demonstrate that particle elasticity directs tumor accumulation, suggesting that it may be a design parameter to enhance tumor delivery efficiency.

Date: 2018
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DOI: 10.1038/s41467-017-02588-9

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