Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration

Héctor Sánchez-Iranzo, María Galardi-Castilla, Carolina Minguillón, Andrés Sanz-Morejón, Juan Manuel González-Rosa, Anastasia Felker, Alexander Ernst, Gabriela Guzmán-Martínez, Christian Mosimann and Nadia Mercader ()
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Héctor Sánchez-Iranzo: Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII)
María Galardi-Castilla: Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII)
Carolina Minguillón: CSIC-Institut de Biologia Molecular de Barcelona Parc Científic de Barcelona C/ Baldiri i Reixac
Andrés Sanz-Morejón: Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII)
Juan Manuel González-Rosa: Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII)
Anastasia Felker: University of Zürich
Alexander Ernst: University of Bern
Gabriela Guzmán-Martínez: Hospital Universitario La Paz, IdiPAZ
Christian Mosimann: University of Zürich
Nadia Mercader: Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII)

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract During development, mesodermal progenitors from the first heart field (FHF) form a primitive cardiac tube, to which progenitors from the second heart field (SHF) are added. The contribution of FHF and SHF progenitors to the adult zebrafish heart has not been studied to date. Here we find, using genetic tbx5a lineage tracing tools, that the ventricular myocardium in the adult zebrafish is mainly derived from tbx5a+ cells, with a small contribution from tbx5a− SHF progenitors. Notably, ablation of ventricular tbx5a+-derived cardiomyocytes in the embryo is compensated by expansion of SHF-derived cells. In the adult, tbx5a expression is restricted to the trabeculae and excluded from the outer cortical layer. tbx5a-lineage tracing revealed that trabecular cardiomyocytes can switch their fate and differentiate into cortical myocardium during adult heart regeneration. We conclude that a high degree of cardiomyocyte cell fate plasticity contributes to efficient regeneration.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02650-6

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DOI: 10.1038/s41467-017-02650-6

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