DNA multi-bit non-volatile memory and bit-shifting operations using addressable electrode arrays and electric field-induced hybridization

Youngjun Song (), Sejung Kim, Michael J. Heller () and Xiaohua Huang ()
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Youngjun Song: University of California, San Diego
Sejung Kim: University of California, San Diego
Michael J. Heller: University of California, San Diego
Xiaohua Huang: University of California, San Diego

Nature Communications, 2018, vol. 9, issue 1, 1-8

Abstract: Abstract DNA has been employed to either store digital information or to perform parallel molecular computing. Relatively unexplored is the ability to combine DNA-based memory and logical operations in a single platform. Here, we show a DNA tri-level cell non-volatile memory system capable of parallel random-access writing of memory and bit shifting operations. A microchip with an array of individually addressable electrodes was employed to enable random access of the memory cells using electric fields. Three segments on a DNA template molecule were used to encode three data bits. Rapid writing of data bits was enabled by electric field-induced hybridization of fluorescently labeled complementary probes and the data bits were read by fluorescence imaging. We demonstrated the rapid parallel writing and reading of 8 (23) combinations of 3-bit memory data and bit shifting operations by electric field-induced strand displacement. Our system may find potential applications in DNA-based memory and computations.

Date: 2018
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DOI: 10.1038/s41467-017-02705-8

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