Closed-loop stimulation of temporal cortex rescues functional networks and improves memory

Youssef Ezzyat, Paul A. Wanda, Deborah F. Levy, Allison Kadel, Ada Aka, Isaac Pedisich, Michael R. Sperling, Ashwini D. Sharan, Bradley C. Lega, Alexis Burks, Robert E. Gross, Cory S. Inman, Barbara C. Jobst, Mark A. Gorenstein, Kathryn A. Davis, Gregory A. Worrell, Michal T. Kucewicz, Joel M. Stein, Richard Gorniak, Sandhitsu R. Das, Daniel S. Rizzuto and Michael J. Kahana ()
Additional contact information
Youssef Ezzyat: University of Pennsylvania
Paul A. Wanda: University of Pennsylvania
Deborah F. Levy: University of Pennsylvania
Allison Kadel: University of Pennsylvania
Ada Aka: University of Pennsylvania
Isaac Pedisich: University of Pennsylvania
Michael R. Sperling: Thomas Jefferson University Hospital
Ashwini D. Sharan: Thomas Jefferson University Hospital
Bradley C. Lega: University of Texas, Southwestern
Alexis Burks: University of Texas, Southwestern
Robert E. Gross: Emory University Hospital
Cory S. Inman: Emory University Hospital
Barbara C. Jobst: Dartmouth-Hitchcock Medical Center
Mark A. Gorenstein: Dartmouth-Hitchcock Medical Center
Kathryn A. Davis: Hospital of the University of Pennsylvania
Gregory A. Worrell: Mayo Clinic
Michal T. Kucewicz: Mayo Clinic
Joel M. Stein: Hospital of the University of Pennsylvania
Richard Gorniak: Thomas Jefferson University Hospital
Sandhitsu R. Das: Hospital of the University of Pennsylvania
Daniel S. Rizzuto: University of Pennsylvania
Michael J. Kahana: University of Pennsylvania

Nature Communications, 2018, vol. 9, issue 1, 1-8

Abstract: Abstract Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction.

Date: 2018
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DOI: 10.1038/s41467-017-02753-0

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