The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma

Irene Soncin, Jianpeng Sheng, Qi Chen, Shihui Foo, Kaibo Duan, Josephine Lum, Michael Poidinger, Francesca Zolezzi, Klaus Karjalainen () and Christiane Ruedl ()
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Irene Soncin: Nanyang Technological University, 60 Nanyang Drive
Jianpeng Sheng: Nanyang Technological University, 60 Nanyang Drive
Qi Chen: Nanyang Technological University, 60 Nanyang Drive
Shihui Foo: Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove
Kaibo Duan: Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove
Josephine Lum: Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove
Michael Poidinger: Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove
Francesca Zolezzi: Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove
Klaus Karjalainen: Nanyang Technological University, 60 Nanyang Drive
Christiane Ruedl: Nanyang Technological University, 60 Nanyang Drive

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Circulating CCR2+ monocytes are crucial for maintaining the adult tissue-resident F4/80hiMHCIIhi macrophage pool in the intestinal lamina propria. Here we show that a subpopulation of CCR2-independent F4/80hiMHCIIlow macrophages, which are the most abundant F4/80hi cells in neonates, gradually decline in number in adulthood; these macrophages likely represent the fetal contribution to F4/80hi cells. In colon adenomas of ApcMin/+ mice, F4/80hiMHCIIlow macrophages are not only preserved, but become the dominant subpopulation among tumour-resident macrophages during tumour progression. Furthermore, these pro-tumoural F4/80hiMHCIIlow and F4/80hiMHCIIhi macrophages can self-renew in the tumour and maintain their numbers mostly independent from bone marrow contribution. Analyses of colon adenomas indicate that CSF1 may be a key facilitator of macrophage self-renewal. In summary, the tumour microenvironment creates an isolated niche for tissue-resident macrophages that favours macrophage survival and self-renewal.

Date: 2018
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DOI: 10.1038/s41467-018-02834-8

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