Sustained micellar delivery via inducible transitions in nanostructure morphology

Nicholas B. Karabin, Sean Allen, Ha-Kyung Kwon, Sharan Bobbala, Emre Firlar, Tolou Shokuhfar, Kenneth R. Shull and Evan A. Scott ()
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Nicholas B. Karabin: Northwestern University
Sean Allen: Northwestern University
Ha-Kyung Kwon: Northwestern University
Sharan Bobbala: Northwestern University
Emre Firlar: University of Illinois at Chicago
Tolou Shokuhfar: University of Illinois at Chicago
Kenneth R. Shull: Northwestern University
Evan A. Scott: Northwestern University

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar nanocarriers with improved bioresorptive capacity and modularity for customization. Modular assembly of FMs from diverse block copolymer (BCP) chemistries allows in situ gelation into hydrogel scaffolds following subcutaneous injection into mice. Upon photo-oxidation or physiological oxidation, molecular payloads within FMs transfer to micellar vehicles during the morphological transition, as verified in vitro by electron microscopy and in vivo by flow cytometry. FMs composed of multiple distinct BCP fluorescent conjugates permit multimodal analysis of the scaffold’s non-inflammatory bioresorption and micellar delivery to immune cell populations for one month. These scaffolds exhibit highly efficient bioresorption wherein all components participate in retention and transport of therapeutics, presenting previously unexplored mechanisms for controlled nanocarrier delivery.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03001-9

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DOI: 10.1038/s41467-018-03001-9

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