Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL

Bandish Kapadia, Nahid M. Nanaji, Kavita Bhalla, Binny Bhandary, Rena Lapidus, Afshin Beheshti, Andrew M. Evens and Ronald B. Gartenhaus ()
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Bandish Kapadia: University of Maryland
Nahid M. Nanaji: Maryland Healthcare System
Kavita Bhalla: University of Maryland
Binny Bhandary: University of Maryland
Rena Lapidus: University of Maryland
Afshin Beheshti: Molecular Oncology Research Institute, Tufts Medical Center
Andrew M. Evens: Molecular Oncology Research Institute, Tufts Medical Center
Ronald B. Gartenhaus: University of Maryland

Nature Communications, 2018, vol. 9, issue 1, 1-15

Abstract: Abstract Altered lipid metabolism and aberrant protein translation are strongly associated with cancerous outgrowth; however, the inter-regulation of these key processes is still underexplored in diffuse large B-cell lymphoma (DLBCL). Although fatty acid synthase (FASN) activity is reported to positively correlate with PI3K-Akt-mTOR pathway that can modulate protein synthesis, the precise impact of FASN inhibition on this process is still unknown. Herein, we demonstrate that attenuating FASN expression or its activity significantly reduces eIF4B (eukaryotic initiation factor 4B) levels and consequently overall protein translation. Through biochemical studies, we identified eIF4B as a bonafide substrate of USP11, which stabilizes and enhances eIF4B activity. Employing both pharmacological and genetic approaches, we establish that FASN-induced PI3K-S6Kinase signaling phosphorylates USP11 enhancing its interaction with eIF4B and thereby promoting oncogenic translation.

Date: 2018
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DOI: 10.1038/s41467-018-03028-y

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