Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses

Courtney S. Malo, Matthew A. Huggins, Emma N. Goddery, Heather M. A. Tolcher, Danielle N. Renner, Fang Jin, Michael J. Hansen, Larry R. Pease, Kevin D. Pavelko and Aaron J. Johnson ()
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Courtney S. Malo: Mayo Clinic
Matthew A. Huggins: Mayo Clinic
Emma N. Goddery: Mayo Clinic
Heather M. A. Tolcher: Mayo Clinic
Danielle N. Renner: Mayo Clinic
Fang Jin: Mayo Clinic
Michael J. Hansen: Mayo Clinic
Larry R. Pease: Mayo Clinic
Kevin D. Pavelko: Mayo Clinic
Aaron J. Johnson: Mayo Clinic

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract The contribution of antigen-presenting cell (APC) types in generating CD8+ T cell responses in the central nervous system (CNS) is not fully defined, limiting the development of vaccines and understanding of immune-mediated neuropathology. Here, we generate a transgenic mouse that enables cell-specific deletion of the H-2Kb MHC class I molecule. By deleting H-2Kb on dendritic cells and macrophages, we compare the effect of each APC in three distinct models of neuroinflammation: picornavirus infection, experimental cerebral malaria, and a syngeneic glioma. Dendritic cells and macrophages both activate CD8+ T cell responses in response to these CNS immunological challenges. However, the extent to which each of these APCs contributes to CD8+ T cell priming varies. These findings reveal distinct functions for dendritic cells and macrophages in generating CD8+ T cell responses to neurological disease.

Date: 2018
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DOI: 10.1038/s41467-018-03037-x

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