Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging

Gabriel Oh, Sasha Ebrahimi, Matthew Carlucci, Aiping Zhang, Akhil Nair, Daniel E. Groot, Viviane Labrie, Peixin Jia, Edward S. Oh, Richie H. Jeremian, Miki Susic, Tenjin C. Shrestha, Martin R. Ralph, Juozas Gordevičius, Karolis Koncevičius and Art Petronis ()
Additional contact information
Gabriel Oh: Centre for Addiction and Mental Health
Sasha Ebrahimi: Centre for Addiction and Mental Health
Matthew Carlucci: Centre for Addiction and Mental Health
Aiping Zhang: Centre for Addiction and Mental Health
Akhil Nair: Centre for Addiction and Mental Health
Daniel E. Groot: Centre for Addiction and Mental Health
Viviane Labrie: Centre for Addiction and Mental Health
Peixin Jia: Centre for Addiction and Mental Health
Edward S. Oh: Centre for Addiction and Mental Health
Richie H. Jeremian: Centre for Addiction and Mental Health
Miki Susic: Centre for Addiction and Mental Health
Tenjin C. Shrestha: University of Toronto
Martin R. Ralph: University of Toronto
Juozas Gordevičius: Vilnius University
Karolis Koncevičius: Vilnius University
Art Petronis: Centre for Addiction and Mental Health

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism’s deterioration.

Date: 2018
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DOI: 10.1038/s41467-018-03073-7

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