A proteomic landscape of diffuse-type gastric cancer

Sai Ge, Xia Xia, Chen Ding, Bei Zhen, Quan Zhou, Jinwen Feng, Jiajia Yuan, Rui Chen, Yumei Li, Zhongqi Ge, Jiafu Ji, Lianhai Zhang, Jiayuan Wang, Zhongwu Li, Yumei Lai, Ying Hu, Yanyan Li, Yilin Li, Jing Gao, Lin Chen, Jianming Xu, Chunchao Zhang, Sung Yun Jung, Jong Min Choi, Antrix Jain, Mingwei Liu, Lei Song, Wanlin Liu, Gaigai Guo, Tongqing Gong, Yin Huang, Yang Qiu, Wenwen Huang, Tieliu Shi, Weimin Zhu, Yi Wang, Fuchu He (), Lin Shen () and Jun Qin ()
Additional contact information
Sai Ge: Institute of Lifeomics
Xia Xia: Institute of Lifeomics
Chen Ding: Institute of Lifeomics
Bei Zhen: Institute of Lifeomics
Quan Zhou: Institute of Lifeomics
Jinwen Feng: Institute of Lifeomics
Jiajia Yuan: Institute of Lifeomics
Rui Chen: Baylor College of Medicine
Yumei Li: Baylor College of Medicine
Zhongqi Ge: Baylor College of Medicine
Jiafu Ji: Peking University Cancer Hospital & Institute
Lianhai Zhang: Peking University Cancer Hospital & Institute
Jiayuan Wang: Peking University Cancer Hospital & Institute
Zhongwu Li: Peking University Cancer Hospital & Institute
Yumei Lai: Peking University Cancer Hospital & Institute
Ying Hu: Peking University Cancer Hospital & Institute
Yanyan Li: Peking University Cancer Hospital & Institute
Yilin Li: Peking University Cancer Hospital & Institute
Jing Gao: Peking University Cancer Hospital & Institute
Lin Chen: General Hospital of Chinese People’s Liberation Army
Jianming Xu: Affiliated Hospital of Academy of Military Medical Sciences
Chunchao Zhang: Baylor College of Medicine
Sung Yun Jung: Baylor College of Medicine
Jong Min Choi: Baylor College of Medicine
Antrix Jain: Baylor College of Medicine
Mingwei Liu: Institute of Lifeomics
Lei Song: Institute of Lifeomics
Wanlin Liu: Institute of Lifeomics
Gaigai Guo: Institute of Lifeomics
Tongqing Gong: Institute of Lifeomics
Yin Huang: Institute of Lifeomics
Yang Qiu: Institute of Lifeomics
Wenwen Huang: Institute of Lifeomics
Tieliu Shi: East China Normal University
Weimin Zhu: Institute of Lifeomics
Yi Wang: Institute of Lifeomics
Fuchu He: Institute of Lifeomics
Lin Shen: Institute of Lifeomics
Jun Qin: Institute of Lifeomics

Nature Communications, 2018, vol. 9, issue 1, 1-16

Abstract: Abstract The diffuse-type gastric cancer (DGC) is a subtype of gastric cancer with the worst prognosis and few treatment options. Here we present a dataset from 84 DGC patients, composed of a proteome of 11,340 gene products and mutation information of 274 cancer driver genes covering paired tumor and nearby tissue. DGC can be classified into three subtypes (PX1–3) based on the altered proteome alone. PX1 and PX2 exhibit dysregulation in the cell cycle and PX2 features an additional EMT process; PX3 is enriched in immune response proteins, has the worst survival, and is insensitive to chemotherapy. Data analysis revealed four major vulnerabilities in DGC that may be targeted for treatment, and allowed the nomination of potential immunotherapy targets for DGC patients, particularly for those in PX3. This dataset provides a rich resource for information and knowledge mining toward altered signaling pathways in DGC and demonstrates the benefit of proteomic analysis in cancer molecular subtyping.

Date: 2018
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DOI: 10.1038/s41467-018-03121-2

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